P087 Monitoring amikacin pharmacokinetics for personal dose optimisation
نویسندگان
چکیده
منابع مشابه
Clinical Pharmacokinetics of Amikacin in Neonates
Amikacin is a bactericidal aminoglycoside. Aminoglycosides inhibit bacterial protein synthesis. The antibacterial spectrum of amikacin is the broadest of aminoglycosides. Because of its resistance to many of the aminoglycosides-inactivating enzymes, it has a special role in hospitals where gentamicin- and tobramycin-resistant microorganisms are prevalent. Amikacin is active against the majority...
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The pharmacokinetics of amikacin were investigated in five stable patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Each patient was studied after the administration of 7.5 mg of amikacin per kg by both the intravenous (i.v.) and intraperitoneal (i.p.) route, allowing a 1-month washout period between doses. No differences in amikacin half-life, volume of distribution, total ...
متن کاملAmikacin Pharmacokinetics During Continuous Veno-Venous Hemodialysis
INTRODUCTION Little is known about the pharmacokinetics of amikacin during continuous renal replacement therapy. METHODS This prospective observational study included patients admitted to an academic medical center who received amikacin therapy while on continuous veno-venous hemodialysis (CVVHD) and had at least two serum sample concentrations measured after first-dose administration. First-...
متن کاملInfluence of sepsis on higher daily dose of amikacin pharmacokinetics in critically ill patients.
BACKGROUND AND OBJECTIVES Severe sepsis is a major problem as cause of high rates morbidity and mortality in intensive care units (ICU). Aminoglycosides are an important group of antimicrobials used for severe sepsis. However, aminoglycoside pharmacokinetics in ICU patients may be altered during sepsis, which can affect the drug concentrations. Therefore, this study was undertaken to examine th...
متن کاملclinical pharmacokinetics of amikacin in neonates
amikacin is a bactericidal aminoglycoside. aminoglycosides inhibit bacterial protein synthesis. the antibacterial spectrum of amikacin is the broadest of aminoglycosides. because of its resistance to many of the aminoglycosides-inactivating enzymes, it has a special role in hospitals where gentamicin- and tobramycin-resistant microorganisms are prevalent. amikacin is active against the majority...
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ژورنال
عنوان ژورنال: Journal of Cystic Fibrosis
سال: 2018
ISSN: 1569-1993
DOI: 10.1016/s1569-1993(18)30384-9